Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
USERS' SCORE
Moderately Good
Based on 26 Reviews
7.7
Supplement Facts
Serving Size: 3 Veg Capsules
Serving Per Container: 40
Amount Per Serving
%DV
GreenGrown® Glucosamine HCl
1.5 g (1,500 mg)
*
MSM (Methylsulfonylmethane)
1 g (1,000 mg)
*
Top Medical Research Studies
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
Most Useful Reviews
9
Knees much better
9 people found this helpful
Glucosamine has greatly improved my joints, especially my knees, which feel better now than they did fifteen years ago. I can play tennis, basketball, do yard work, and take dance lessons weekly. This improvement is remarkable, considering I thought I'd have to limit my activities.
Read More
7.5
Knee improved quickly
5 people found this helpful
My knee felt better in just three days after starting this product. I've managed to improve my knee condition quite well, despite my scepticism regarding placebo effects.
Read More
9
Knees improved greatly
3 people found this helpful
I adore this product! I began using it for my knees years ago and found no need to try other brands since discovering this one. After pausing for rotator cuff surgery last year, my knees ached terribly, but these two capsules daily make all the difference!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
- All Researches
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
8
We assessed the impact of an 8-week joint pain supplement, Instaflex™, on adults aged 50-75 experiencing knee pain. In a randomized, double-blind, placebo-controlled trial with 100 participants, we measured changes in pain, stiffness, and daily function.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Read More
7
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
Read More
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 26 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Knees much better
9 people found this helpful
Glucosamine has greatly improved my joints, especially my knees, which feel better now than they did fifteen years ago. I can play tennis, basketball, do yard work, and take dance lessons weekly. This improvement is remarkable, considering I thought I'd have to limit my activities.
Read More
7.5
Knee improved quickly
5 people found this helpful
My knee felt better in just three days after starting this product. I've managed to improve my knee condition quite well, despite my scepticism regarding placebo effects.
Read More
9
Knees improved greatly
3 people found this helpful
I adore this product! I began using it for my knees years ago and found no need to try other brands since discovering this one. After pausing for rotator cuff surgery last year, my knees ached terribly, but these two capsules daily make all the difference!
Read More
9
Knees greatly improved
3 people found this helpful
Very good! My knees have significantly improved, much better than before using it.
Read More
10
Sore knees eliminated
2 people found this helpful
Joseph Escriva Glucosamine with MSM has been and will likely remain in my personal use for a long time. It has helped eliminate sore knees.
Read More
Frequently Asked Questions
7.5
Knee improved quickly
5 people found this helpful
My knee felt better in just three days after starting this product. I've managed to improve my knee condition quite well, despite my scepticism regarding placebo effects.
9
Knees feel better quickly
2 people found this helpful
After running out of glucosamine, my knees began to hurt again. As soon as I resumed taking it, I felt better very quickly. It's suitable for vegetarians and those with sensitivities to shellfish.
7
Feeling better overall
1 people found this helpful
I've been taking it for over two months, and my knees are feeling better. I’ll continue using this vegetarian form as I don’t eat meat or drink milk. I love it!
6
Joint improvement noted
4 people found this helpful
My knee and wrist joints are getting better. I have been taking it for six weeks. My knee has felt a little stiff at first, but it's improving. My wrist joints have also shown improvement.
9
Knees much better
9 people found this helpful
Glucosamine has greatly improved my joints, especially my knees, which feel better now than they did fifteen years ago. I can play tennis, basketball, do yard work, and take dance lessons weekly. This improvement is remarkable, considering I thought I'd have to limit my activities.
9
Effective for healing
1 people found this helpful
I have participated in sports for over 20 years. For problems with knee, elbow joints and ligaments, I use this treatment, which helps with healing very well. Highly recommend!
2
No relief achieved
1 people found this helpful
Honestly, this had no effect on my joints. My knee pain persists even while taking it. I regret buying it and will not purchase again.
7.5
Improvement in pain
1 people found this helpful
I have arthrosis and have tried different glucosamine products. This one is my favourite. Along with vitamin D and Omega, I've noticed a definite improvement; my knees are easier, and the joint pain has reduced significantly. I highly recommend it!
9
Knees improved greatly
3 people found this helpful
I adore this product! I began using it for my knees years ago and found no need to try other brands since discovering this one. After pausing for rotator cuff surgery last year, my knees ached terribly, but these two capsules daily make all the difference!
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
7
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
References
- Toguchi A, Noguchi N, Kanno T, Yamada A. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. 10.3390/nu15132995
- Tennent DJ, Hylden CM, Kocher BK, Aden JK, Johnson AE. A randomized controlled trial evaluating methylsulfonylmethane versus placebo to prevent knee pain in military initial entry trainees. US Army Med Dep J. 2017.
- Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, et al. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J. 2013;12:154. 10.1186/1475-2891-12-154
- Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50. 10.1186/1472-6882-11-50
- Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286.
